1 months 187 (51%) underwent normal vaginal learn more delivery, 54 (15%) underwent vacuum/forceps delivery and 126 (34%) underwent cesarean section. A total of 32 women (15%) complained of new onset postpartum stress urinary incontinence. A generalized increase in urethral mobility was observed after childbirth (each p <= 0.003), which was associated only
with delivery mode at the proximal urethra (p <= 0.02) Peripartum changes in urethral mobility did not differ significantly between women with and without de novo stress urinary incontinence (each p >0.6).
Conclusions: There seems to be a generalized increase in urethral mobility after childbirth but this change does not seem to be associated with de novo SUI.”
“Amyloid beta (A beta) plays a central role in Alzheimer’s disease
(AD) and binds to the nicotinic alpha(7) receptor (alpha(7) nAChR). Little is known about the degree to which the binding of A beta to the alpha(7) nAChR influences the role of this receptor in long-term potentiation (LIP), however. We have studied the effect of the partial alpha(7) nAChR agonist SSR180711 on hippocampal ERK inhibitor slice preparations from normal wild type (Wt) and APP(swe)/PS1 Delta E9 transgenic (Tg) mice. In the hippocampal slices from the 6 months old Wt mice, the application of both nicotine (5 mu M) and SSR180711 (300 nM) resulted in a significant enhancement of LIP expressed in area CA1. However, in the Tg mice the application of SSR180711 did not result in an increase in LTP beyond control levels. The amount of binding of the alpha(7) nAChR ligand 125-I-alpha-bungarotoxin was not different between in Tg and Wt mice. These findings indicate that the alpha(7) nAChR is functionally blocked in the hippocampal neurons, downstream of the alpha(7) nAChR, and that this is likely due to an interaction between the receptor and A beta, which leads to changes in LIP. (C) 2010 Elsevier Ireland Ltd. All rights reserved.”
“Purpose: Holmium laser enucleation of the prostate is highly effective for symptomatic benign prostatic hyperplasia. Despite its
steep learning curve the procedure is an efficient treatment, especially for large prostate glands. We determined the change in enucleation efficiency with time with increased operative Transmembrane Transporters modulator experience and improved technique.
Materials and Methods: We reviewed the records of all 949 consecutive men who underwent holmium laser enucleation of the prostate between 1999 and 2007. Patients were excluded from analysis when enucleated gm or time was not recorded and enucleated tissue was less than 5 gm. Efficiency was measured in gm enucleated prostate tissue per minute. Descriptive statistics on laser time, gland weight and efficiency were evaluated in an 8-year period.
Results: A total of 91 patients met study exclusion criteria, leaving 858 available for evaluation. Mean enucleation time was 94 minutes (range 12 to 485). Mean prostate specimen weight was 77 gm (range 5 to 376).