However, because Mn exposure potentiated the LPS-induced nuclear expression of small Maf proteins, this may be one mechanism Mn uses to affect the expression of HO-1 in activated microglia. Finally, the potentiating effects of Mn on HO-1 appear to be glia-specific for Mn, LPS, or Mn + LPS did not induce HO-1 in N27 neuronal cells. (C) 2011 Elsevier Inc. All rights
“Biological and psychosocial factors affect child development and behavior. Whereas XL184 clinical trial biological underpinnings behind the neurotoxic effects of lead are studied extensively, the effects of psychosocial factors contributing to poor behavioral outcomes in lead-exposed children are not well understood. Parental attributes and practices may moderate or mediate the effects of lead on children’s behavioral outcomes. We investigated the hypothesis that maternal and child lead and hemoglobin levels Selleck VE-822 are associated with maternal perceptions of their parenting. Specifically, we hypothesized that children with higher blood lead (BLL) and lower hemoglobin concentrations would be associated with poorer maternal self-assessments of their parenting skills or the mother-child relationship. Children aged 13-55 months and their mothers (n = 109) were recruited from among the participants of a previous
lead and anemia screening study and from preschools in Montevideo, Uruguay. The mother-child pair attended two study visits: one to collect biological samples and answer demographic and child questionnaires, including statements regarding parenting; and a second to evaluate maternal IQ depression and stress, and child development. Of the children, 51.6% had blood lead concentrations (BLLs)
>= 5 mu g/dL, 18.0% had anemia, and 8% had both conditions. Among mothers, 48.4% had BLLs >= 5 mu g/dL, 16.0% had anemia, and 11% had both. BLLs >= 5 mu g/dL in mother or child were associated with lower maternal perceptions of being skilled at discipline (p < 0.05). Maternal anemia was associated with lower likelihood that mothers would let their children explore and play QNZ cell line (p < 0.05), whereas child anemia was associated with maternal perception of lower emotional support (p < 0.01). In addition to shared environmental exposures, parenting and family interactions need to be considered as potentially contributing factors to poorer outcomes in lead-exposed children. (C) 2011 Elsevier Inc. All rights reserved.”
“A number of epidemiological studies have demonstrated a strong association between the incidence of neurodegenerative disease and pesticide exposure. Fluazinam (FZN) is a preventative fungicide from the pyridinamine group that was introduced in the 1990s and that quickly established itself as a new standard for the control of blight caused by Phytophthora infestans in potatoes.