Thus,

Thus, Vorinostat supplier the TCR-defined subsets express CD27 differentially, and their functional development might be determined accordingly, presumably by a combination of TCR and CD27-derived signals. Interestingly, although this is not discussed at length, Supporting Information Fig. 6 in the current paper 8 also shows a substantial difference in CD27 expression by Vδ2+ versus Vδ1+ human γδ T cells. Here, although CD27 expression in the Vδ1+ subset is more heterogeneous, a large fraction of these cells

express the molecule at nearly 10-fold higher levels than Vδ2+ cells. Because functional differences between human Vδ1+ and Vδ2+γδ T cells have been reported 15, perhaps combined influences of TCR and CD27 signaling determine functional differentiation here also (Fig. 1). In addition to the TNF-receptor family member CD27, which is also expressed by other lymphocyte types 3, mouse and human γδ T cells are known

to express TNF-R2 17, which is not normally expressed PI3K inhibitor by αβ T cells, as well as Fas 18, and CD30 19. As is the case with CD27, several TNF receptor family members, including HVEM, OX40, 4-1BB and CD30, are recognized as important costimulators in initiating and sustaining the T-cell response and in promoting long-lived immunity 20. Perhaps certain other TNF-receptors expressed by γδ T cells, e.g. CD30, might function as costimulators on γδ T cells as well. However, it remains to be seen whether any of those are also capable of influencing γδ T-cell functional bias, SB-3CT as is shown here with CD27 8. The authors thank the National Institutes

of Health (1R56A1 077594) and National Jewish Health for their support. Conflict of interest: The authors declare no financial or commercial conflict of interest. See accompanying article: http://dx.doi.org/10.1002/eji.201040905 “
“In recent years, it has become apparent that the removal of apoptotic cells by macrophages and DC is not only noninflammatory, but also immune-inhibitory, in most although not all circumstances. Complement may be involved in the uptake of apoptotic cells via direct binding of bridging factors in some physiological circumstances, by opsonization and engagement of the complement receptors. In the current study, we use a complement-dependent system of apoptotic cell clearance by human-derived macrophages and DC. Using a luciferase reporter gene and measuring immune response to non-opsonic zymosan, we show that iC3b-apoptotic cells induce NF-κB inhibition in response to zymosan and LPS at the nuclear translocation, transcriptional and post-transcriptional levels, leading to profound inhibition of proinflammatory cytokines. In addition, interaction with iC3b-opsonized apoptotic cells is characterized by macrophage secretion of IL-10 and lack of TGF-β secretion. In conclusion, in cells with iC3b receptors, opsonized apoptotic cells mediate a distinct anti-inflammatory response and transcriptional NF-κB-dependent blockage.

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