The aim of this study was to retrospectively evaluate the outcome of a contemporary series of 14 consecutive bladder neuroendocrine neoplasms observed at 2 institutional hospitals. Materials and Methods: Thiazovivin supplier The charts of patients with a pathological diagnosis of neuroendocrine bladder tumours observed at 2 institutions

in the last 5 years were reviewed. Fourteen cases were retrieved. The main endpoint was to evaluate the pathological features and the cancer-specific survival (CSS) of the cohort. Subanalysis of survival based on the type of treatment received was attempted. Results: Mean age was 70.2 years. The rate of metastatic disease at diagnosis was 57.1%. Mean follow-up was 13.7 months (95% CI 5.1-22.3). The 6-month CSS rate was 57.1%, while the 2-year CSS rate was 21.4%. CSS and overall survival rates overlapped. The median survival for the cohort was 7 months. There was no statistically significant difference in survival between patients who underwent surgery and those who

did not. Conclusion: Neuroendocrine bladder tumours remain a disease with an extremely unfavourable prognosis. The impact of radical surgery on survival remains questionable. Patients harbouring this rare bladder cancer should be referred for trials assessing neoadjuvant and adjuvant systemic treatment strategies. Copyright (c) 2010 S. Karger AG, Basel”
“The effect of aqueous leaf extract of Ocimum gratissimum was investigated in rat models of liver injury induced by carbon tetrachloride (CCl4). Treatment of separate groups EGFR inhibition of rats with 2.5 ml/kg body weight of 5, 10 and 15% aqueous extracts of O. gratissimum for 3 weeks after establishment of CCl4 induced liver damage, resulted in significantly (p < 0.05) less hepatotoxicity than with CCl4 alone, as measured by serum alkaline phosphatase (ALP), alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities. For serum alanine aminotransferase, activity decreased from 68.95 +/- 21.38 U/l to 35.77 +/- 1.48 U/l, while for aspartate aminotransferase, activity level decreased from 165.65 +/- 17.75 to 110.10 +/- 3.05 U/l and for find more alkaline

phosphatase, activity level decreased from 364.65 +/- 37.75 to 212.74 +/- 15.27 U/l. The reduction though not statistically significant (p < 0.05) was dose dependent. Histopathological findings also suggest that treatment with aqueous extracts of O. gratissimum after establishment of CCl4-induced liver damage significantly reduced and even reversed the liver damage in the rats. The results of the study indicate that O. gratissimum might be an effective plant hepatoprotector in the diet of patients with hepatopathies.”
“Spinel ferrite flakes Ni(0.97-x)Zn(x)Co(0.03)Fe(2)O(4) with x=0.5 and 0.65 are prepared for use as fillers in electromagnetic composites. The composites with the flaky fillers exhibit greatly enhanced high-frequency and attenuation properties.