Separation was achieved on C18 column (250X4.6mm i.d., 5 mu m) in isocratic mode using methanol and water in the ratio 90: 10 (v/v) as mobile phase, pumped in to the column at flow rate of 1 ml/min and the detection of eluent from the column was carried out using variable wavelength detector at 280 nm. The total run time was 10 min and the column was maintained at ambient temperature. The retention times of rimonabant hydrochloride and saquinavir mesylate were 5.760 min and 4.657 min, respectively. The Cyclopamine standard curves were linear over the concentration range of 0.2-10 mu g/ml and the LOD and LOQ values for rimonabant hydrochloride were 0.0113 mu

g/ml and 0.0345 mu g/ml, respectively. The percentage recovery was found to be 100 to 100.22 and the % RSD of intraday and inter day precision was found to 5-Fluoracil molecular weight be 0.572 and 0.549, respectively. The percentage amount of two different marketed tablet formulation of rimonabant hydrochloride was found to be 100.4 and 100.5%. The method was validated as per ICH guidelines. Validation studies demonstrated that the proposed RP-HPLC method is simple, specific, rapid, reliable and reproducible. The high recovery and low relative standard deviation confirm the suitability of the

proposed method for the routine quality control analysis of rimonabant hydrochloride in bulk and tablet dosage forms.”
“In this study, novel acrylonitrile butadiene rubber (NBR) nanocomposites with improved electrical conductivity and mechanical properties were synthesized. Carbon nanoparticles (CNP)/NBR composites and CNP-polyethylene/NBR nanocomposites were prepared by mixing via two-roll mill. The first type of the nanocomposite was produced to determine the percolation threshold concentration (Vc). The second type with constant CNP concentration, slightly over Vc (0.2 vol %), was synthesized to investigate the influence of polyethylene content on the mechanical, electrical

and swelling behavior of nanocomposites. Only the nanocomposites with 3 vol % polyethylene loading showed electrical conductivity. However, the composites with higher polyethylene loadings showed insulating behavior due to hindrance of CNP network by polyethylene layers. Swelling measurements revealed that Z-IETD-FMK purchase the change in entropy of the swelling increased with the increase in disorder level but decreased with the increase in intercalation level of CNP in the disordered intercalated nanocomposite. The increase in solvent uptake was comparable with the free volume in NBR matrix upon inclusion of nanoparticles, whereas the inhibition in solvent uptake for higher polyethylene loading was described by bridging flocculation. (c) 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2012″
“The involvement of nitrergic mechanisms in the behavioural effects of withaferin A in rats was studied in the elevated plus-maze, open-field and rotarod tests. Administration of the nitric oxide (NO) precursor L-arginine (100 mg/kg, i.p.