Results were heterogeneous, but we identified a trend supporting that the construction of a longer Roux-limb is more efficient in super obese patients. This review suggests that the tailoring of a longer Roux-limb might only be efficient in super obese patients. The overall limited quality of the included studies prompts to call for improvement in trial design in surgery.”
“Objective: Extracellular inorganic pyrophosphate (ePPi) plays a key role in the regulation of normal and pathologic mineralization. The purpose
of this work was to evaluate the role of P1 and P2 purine receptors in modulating ePPi production by GSK461364 mw articular chondrocytes.
Methods: Porcine cartilage explants and chondrocyte monolayers were cultured in the presence of P1 agonists, or a P2 agonist or antagonist and inhibitors of P2 signaling. Ambient media ePPi concentrations were measured after 48-96 h.
Results: The P1 agonists NECA and CGS 21680 significantly decreased ePPi concentrations surrounding chondrocytes and cartilage CCI-779 mouse explants. The P2 agonist, ADP, increased ePPi levels, and the P2 antagonist, suramin, decreased ePPi concentrations. Thapsigargin and 1,2 bis-(2-aminophenoxy)ethane-N,N,N’N'-tetra acetic acid (BAPTA), which dampen Ca(2+)-related P2 signaling, suppressed the response to ADP.
Conclusions: Purine receptors are important
regulators of ePPi production by chondrocytes. P1 receptor stimulation diminishes and P2 receptor stimulation enhances ePPi production. Alterations in receptor signaling or aberrations of extracellular purine nucleotide metabolism resulting in abnormal quantities or proportions of P1 and P2 receptor ligands could foster changes in ePPi production that in turn affect mineralization. We propose a homeostatic role for extracellular purine nucleotides and purine receptors in stabilizing ePPi concentrations. (C) 2010 Osteoarthritis Research Society International. Published by Elsevier Ltd. All
rights reserved.”
“Background: The impact of non-motor symptoms (NMS) on the Health-Related Quality of Life (HRQoL) of patients with Parkinson’s disease (PD) in the Chinese population are largely unknown.
Objectives: To study the impact of NMS on the HRQoL in Chinese PD patients.
Methods: see more A total of 693 PD patients from Southwest China were included in the study. NMS of patients were evaluated by non-motor symptoms scale (NMSS) and Parkinson’s disease questionnaire-39 item version (PDQ-39) was used to evaluate the HRQoL of PD.
Results: The mean total score of NMSS was 37.2 +/- 33.0 and the most prevalent NMS domain was sleep/fatigue (79.8%). There was a significant strong positive correlation between total NMSS score (r(s) = 0.71, P < 0.01), sleep/fatigue domain (r(s) = 0.60, P < 0.01) and PDQ-39 SI. Mood/apathy (r(s) = 0.55, P < 0.01), attention/memory (r(s) = 0.42, P < 0.01), gastrointestinal (r(s) = 0.44, P < 0.