Patients with Crohn’s disease were more likely to be tested but there were no other factors that predicted screening practices in this setting. Inadequate screening could lead to preventable morbidity and mortality from fulminant flares and long term complications. Moreover, antiHBs were not routinely tested, resulting in potentially missed vaccination opportunities. T TRAN,1 D VAN DER POORTEN1

1Storr Liver Unit, Westmead Millennium Institute, University of Sydney, Westmead, New South Wales, Australia Introduction: Coffee caffeine consumption (CCC) has been shown to have a protective effect on fibrosis progression in hepatitis C and is associated with reduced mortality from alcoholic cirrhosis and HCC. Emerging evidence has suggested

CCC protects find more against severe forms of Nonalcoholic Steatohepatitis (NASH), but data has been conflicting. We aimed to clarify the association between caffeine intake, in particular coffee caffeine, in a well characterized cohort of patients with biopsy proven Nonalcoholic fatty liver disease (NAFLD). Methods: A validated questionnaire was utilized to determine the caffeine consumption of patients with biopsy proven NAFLD based on their daily consumption of coffee, tea, click here and soft drinks. All patients had fasting blood tests and anthropometric measurements taken on the day of liver biopsy. Liver biopsies were scored using Brunt’s criteria and patients were characterized as having either simple

steatosis or NASH. Caffeine consumption was compared to histological scores including Ballooning, Portal Inflammation, Steatosis and Fibrosis and to markers of liver inflammation and metabolic disturbance. Correlations were made using Spearman Y-27632 chemical structure rank test, while t tests and Chi Square were used to compare categorical variables. Results: 232 patients were included for analysis, 73 with simple steatosis and 159 with NASH. The mean age of the cohort was 57 and 45.7% were females. Average coffee consumption for the cohort was 10.36 cups/wk or 0.623 grams CCC/wk. There was no difference in overall or CCC between patients with steatosis (10.25 cups/wk), mild NASH (9.77 cups/wk) and severe NASH (10.80 cups/wk). Furthermore, in patients with NASH, there was no correlation between overall or CCC and histological liver changes of Fibrosis, Steatosis, Ballooning, Portal Inflammation, Lobular Inflammation, or Mallory’s Hyaline grade. (p > 0.05). There was no correlation between CCC and ALT, BMI or other key metabolic parameters. Conclusion: Caffeine consumption does not appear to have a protective effect in NASH. Larger studies are needed to determine if specific groups may benefit from increased coffee caffeine.