Over the years, a number of single & multi-parameter predictors have been identified & tested for assessing the severity of this disease. The aim of our study is to emphasize that serum Procalcitonin (PCT); a maker of systemic selleck screening library inflammation, is an effective single bio-marker in determining the severity of AP early in the disease process. Methods: We conducted a prospective study on 166 patients fulfilling the Atlanta Criteria, who were categorized into 2 groups of mild versus severe AP based on the Glasgow Scoring System. The value

of PCT as a prognostic marker was compared to C – reactive protein (CRP) and Hematocrit (HCT), by obtaining these values at 0, 24, and 48 hours. Results: Out of 166 patients, 32 were graded as severe, while 134 were graded as mild cases of AP according to the modified Glasgow criteria. Based on the measurements at 0, 24 and 48 hours from the time of admission, it was observed that PCT levels reached their peak values within 24 hours, as compared to CRP levels,

which took an average Selleck Acalabrutinib of 72 hours to reach the peak. Serum PCT values were significantly higher in severe cases. In predicting the severity within 24 hours of admission, the sensitivity and specificity of PCT were 92% & 78% respectively, in comparison with CRP where they were 82% & 80% respectively. Hemoconcentration on admission was found in 64% of the patients with severe AP. The values of serum PCT were directly proportional to the duration of hospital stay in these patients. Conclusion: Serum Procalcitonin can be a promising

single bio-marker in predicting the severity of Acute Pancreatitis. Key Word(s): 1. procalcitonin; 2. acute pancreatitis; 3. glasgow score; Sorafenib datasheet 4. severity prediction; Presenting Author: RITAMBHRANADA DUSEJA Additional Authors: DEEPAKKUMAR BHASIN, SURINDER RANA, RAJESH GUPTA, L KAMAN, TD YADAV, AMIT RAWAT, KUSUM JOSHI Corresponding Author: RITAMBHRANADA DUSEJA Affiliations: PGIMER Objective: IgG4 related pancreato-biliary pathology can present as pancreatic head mass or obstructive jaundice mimicking malignancy and surgery is done. It has specific diagnostic histomorphology and immunohistology and is amenable to medical treatment. AimThis retrospective study was done to identify IgG4 related pancreato-biliary pathology in pancreatic / hepatic resections done for pancreatic masses or obstructed biliary system respectively. Methods: Hematoxylin and eosin stained slides of pancreatic/hepatic resections over the period of 9 years(2004 -2012) were reviewed. Cases were diagnosed as autoimmune pancreatitis(AIP) or IgG4 related autoimmune sclerosing cholangitis(AIC) based on clinical, radiological and histological details. Immunohistochemistry for IgG4 was done in suspected cases. Serum IgG4 levels and other organs assessment was done. Results: Pancreatic (n-142) and hepatic (n-54) resections done for presumed malignancy done over last 9 years were reviewed. Five patients (3.