On the other hand, transient small bowel intussusceptions (ileo-ileal) are common, generally asymptomatic or mildly symptomatic and usually resolve spontaneously . Cases of pediatric intussusception that presented to a large tertiary care centre in southern India from January 2010 to August 2013 were retrospectively
reviewed in 2013. This facility also served as the primary referral facility for intussusception cases identified through active surveillance during a phase III rotavirus vaccine trial which recruited 1500 children from April 2011 to November 2011 and followed them until they reached 2 years of age, with follow up ending in September 2013. The analysis of safety data in the phase III trial did not reveal any statistically significant difference in the incidence of intussusception meeting Brighton level 1 diagnostic certainty in vaccinees or placebo recipients Antidiabetic Compound Library cell assay . We describe the presentation, management and outcomes of children with intussusception who presented routinely at find more the hospital
(defined as non-surveillance intussusception cases collected by retrospective analysis) as well as those who were detected through an active surveillance program as a part of safety monitoring of the vaccine trial (defined as surveillance intussusception cases). This study may inform appropriate implementation and interpretation of intussusception surveillance post-licensure of rotavirus vaccines in similar developing Sclareol country settings. A retrospective review of all children 0–2 years of age with intussusceptions treated between 1st January 2010 and 31st August 2013 at Christian
Medical College and Hospital (CMC), Vellore was undertaken. This hospital with 2695 beds caters to 1.9 million outpatients and 120,000 inpatients annually, is the largest healthcare facility in the region and is the sole provider of pediatric surgery services in Vellore district, which has a population of about four million people. Cases were identified in a two-step process. Possible cases of intussusception were first identified by an electronic search of the radiology database and operation registers. Ultrasound reports of all children who had an ultrasound of the abdomen were searched for keywords related to intussusception. All children less than 2 years of age with an ultrasound diagnosis of intussusception requiring intervention were included in the study. The diagnosis of intussusception was then confirmed by reviewing the medical records, operation notes and other investigations and entered into a database by one of the investigators. Additionally, as part of safety surveillance of a phase III rotavirus vaccine trial, 1500 infants recruited between April and November 2011 at the age of 6 weeks were randomized in a 2:1 ratio of vaccine to placebo and were actively followed up with weekly contacts by field workers until they reached two years of age.