32nd Maclean KH, Kastan MB, JL Cleveland. ATM deficiency affects both apoptosis and increased proliferation Ht 2-Myc-induced lymphomas. Mol Cancer Res 2007; 5:705 11 . 33rd Matsuoka S, Ballif BA, Smogorzewska A., McDonald ER III, Hurov KE, Luo J, Bakalarski CE, Zhao Z, N mini solos, Lerenthal Y, Y Shiloh, SP Gygi, SJ Elledge. NVP-LDE225 LDE225 ATM and ATR substrate analysis reveals extensive protein networks based on DNA-Sch To. Science 2007; 316:1160 166th 34th Maya R, Balass M, Kim ST, Shkedy D, Leal JF, Shifman O, Moas M, Buschmann T, Ronai Z, Shiloh Y, Kastan MB, Katzir E, Oren M. ATM-dependent Independent phosphorylation of Mdm2 on serine 395 : r in the activation of p53 by the DNA Sch. Genes Dev 2001, 15:1067 077 . 35th McManus KJ, Hendzel MJ.
Mitotic phosphorylation of ATM-dependent Ngigen DNA damage-independent Independent H2AX in normally growing south Mammalian cells. Mol Cell Biol 2005; 16:5013 025th 36th Palmero I, Pantoja C, Serrano M. p19ARF links the tumor suppressor p53 ras. Nature 1998, 395:125 26 . 37th Purdie CA, Harrison DJ, Peter A, Dobbie L, White S, Howie SEM, Salter DM, Bird CC, Wyllie AH, Hooper ML, Clarke AZD2281 AR. Tumor incidence, spectrum and the PLO The at M Mice with a big s deletion in the p53 gene. Oncogene 1994; 9:603 09th 38th Pusapati RV, RJ Rounbehler, S Hong, JT Powers, Yan M, Kiguchi K, McArthur MJ, Wong PK, Johnson DG. ATM f Promotes apoptosis and suppresses tumorigenesis in response to Myc. Proc Natl Acad Sci U S A 2006; 103:1446 451 . 39th Quintanilla M, Brown K, Ramsden M, Balmain A. Carcinogen-specific mutation and amplification of Ha-ras in mouse skin carcinogenesis.
Nature 1986; 0th 322:78 40th Rogakou EP, Pilch DR, Orr AH, Ivanova VS, Bonner WM. DNA double-strand breaks induce histone H2AX phosphorylation on serine 139th Journal of Biological Chemistry, 1998; 273:5858 868th 41st Sherr CJ. Divorcing ARF and p53: an outstanding F ll. Nat Rev Cancer 2006 6:663 73 . 42nd Shieh SY, Ahn J, Tamai K, Taya Y, the windmill C. The human homologs of the kinases Chk1 and checkpoints On Cds1 phosphorylate p53 at multiple DNA damage-inducible sites. Genes Dev 2000; 14:289 00 . 43rd Shiloh Y. The ATM-mediated DNA-Sch the answer: taking shape. Trends Biochem Sci 2006; 31:402 10th 44th Stiff T, O �D riscoll million, Rief N, Iwabuchi K, M Lobrich, Jeggo PA. ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation.
Cancer Res 2004; 64:2390 396 . 45th Taylor AMR, Metcalfe JA, Thick J, Mak YF. Leuk Premiums and lymphomas in ataxia telangiectasia. Blood 1996, 87:423 38 . 46th Timme TL, Thompson TC. Rapid allelotype analysis of p53 knockout mice M-. Biotechniques 1994; 17:462 63rd Bailey et al. Page 9 Mol Cancer Res author manuscript in PMC 2009 1 July. NIH-PA Author Manuscript NIH-PA Author Manuscript NIH-PA Author Manuscript 47th Vasioukhin V, Degenstein L, Wise B, Fuchs E. The magical touch: genome targeting in epidermal stem cells induced by tamoxifen application to the skin of mice M. Proc Natl Acad Sci U S A 1999; 96:8551 556 . 48th Vousden KH, Lu X. Live and let die, or: The cell �s reaction to p53. Nature Rev Cancer 2002 04th 2:594 49th Westphal CH, Rowan S, Schmaltz C, Elson A, Fisher DE, leather P.
atm and p53 together, apoptosis and suppression of tumorigenesis, but not in resistance to acute toxicity t radiation. Nature Genet 1997; 16:397 01 . 50th Xu Y, Ashley T, Brainerd EE, Bronson RT, Meyn MS, Baltimore D. Targeted destruction Tion of ATM leads to Wachstumsst Changes, chromosomal fragmentation may need during the meiosis, immune defects and thymic lymphoma. Genes & Dev 1996; 10:2411 422nd 51st Xu Y, Baltimore D. Two r The ATM in the cellular Ren response to radiation and controlled On cell growth. Genes & Dev 1996; 10:2401 410 . Bailey et al. Page 10 Mol Cancer Res author manuscript in PMC 2009 1 July. NIH-PA Author Manuscript NIH-PA Author Manuscript NIH