No transmissions were observed in the UK and Ireland among the 464 pregnancies managed by zidovudine monotherapy and PLCS between 2000 and 2006 reported to the NSHPC. The median delivery VL in these women was 400 (IQR 61–1992) HIV RNA copies/mL [1]. 5.3.5 Women who do not require treatment

for themselves should commence temporary HAART at the start of the second trimester if the baseline VL is >30 000 HIV RNA copies/mL plasma. (Consider starting earlier if VL > 100 000 HIV RNA copies/mL.) Grading: 1C VL data also influence recommendations relating to mode of delivery (see below). Major determinants of the probability of achieving a VL <50 HIV RNA copies/mL plasma by the time of delivery are the baseline untreated VL and the time available to achieve this target. In the Mma Bana Alpelisib order study, VLs <400 HIV RNA copies/mL plasma were achieved by the time of delivery in 96% (lopinavir/ritonavir-based) to 100% (abacavir/lamivudine/zidovudine) of mothers with baseline VL <1000 HIV

RNA copies/mL plasma and in 86% (lopinavir/ritonavir-based) to 90% (abacavir/lamivudine/zidovudine) if baseline VL >100 000 HIV RNA copies/mL. When therapy was initiated at 31–34 weeks, only 78% of mothers on PI-based therapy had achieved this target [21]. Data from a UK multicentre study retrospectively analysing therapy outcomes in pregnant women initiating HAART at a median gestation of 23 weeks demonstrate very Selleckchem Gemcitabine low rates of complete suppression in women with a baseline VL in the upper quartile (>32 641 HIV RNA copies/mL) with only 46% achieving <50 HIV RNA copies/mL by 36 weeks' gestation (the data point used to make most delivery management decisions) and this fell to 37% for VLs >100 000 HIV RNA copies/mL [88]. For all VLs >10 000 HIV RNA

copies/mL, treatment initiation later than 20.3 weeks’ gestation was associated with significantly less likelihood of successful VL suppression. To address this, the Writing Group recommend that HAART should be commenced at the start of the second trimester, or as soon as possible thereafter, in women with a baseline VL >30 000 HIV RNA copies/mL plasma. 5.4.1 A woman who presents after 28 weeks should commence HAART without delay. Grading: Fossariinae 1B Late presentation after 28 weeks and before the onset of labour occurs less frequently since the introduction of the routine offer and recommendation of antenatal HIV screening. With improved turnaround times for VL testing, a woman presenting beyond 28 weeks may still be managed with a view to a possible vaginal delivery if she commences HAART and achieves a VL <50 HIV RNA copies/mL by 36 weeks. Where women present between 24 and 28 weeks, the advantages of more detailed assessment and tailoring of the regimen should be weighed against the advantages of initiating HAART immediately. The turnaround time for CD4 cell counts, VL and viral resistance tests will impact on this choice. 5.4.