Material and methods. Through the data of a specialized colorectal cancer Registry, we evaluate the clinical and pathological features of the polyps. Trend analysis was assessed with the Joinpoint Regression Program. Results.
A total of 172 patients with malignant polyps were diagnosed throughout the study (3.5% of 4.835 registered patients); their overall frequency during the registration period increased from zero cases in the initial years (1984-85) to 57 cases in the past 3 years (2006-2008). Crude incidence rate passed from 0.37 in 1986-89 to 10.2 in 2006. Joinpoint trend analysis of crude rates showed a significant increase of incidence during the study period, with percent of annual variation ranging between 38.6% (95% CI 12.5-70.7) and 7.3% (95% CI 2.6-12.1). During the screening
period (2005-2008, the past 4 years of registration) there was a significant increase of sessile polyps mTOR inhibitor (p < 0.001), while other clinical and morphological features, including the number of low-and high-risk CYT387 malignant polyps, remained unchanged. The surgery (after polypectomy) tended to raise both in low-and high-risk subgroups. Conclusion. The incidence of malignant polyps increased significantly from the initial to the most recent periods of colorectal cancer registration. Screening was associated with changes in gross morphology of polyps and with an increased use of the surgery after endoscopic polypectomy.”
“Objective. Autofluorescence imaging (AFI) systems may allow better visualization of colorectal neoplasia than conventional methods. However, this is difficult to demonstrate objectively. Recently, a second-generation AFI system with a noise-reduction algorithm was developed. We aimed to objectively evaluate the visualization of colorectal neoplasia by using a second-generation AFI system and software to calculate the color-contrast index. Material and methods. Selleck RG7420 We retrospectively reviewed 53 consecutive colorectal neoplasias examined using the second-generation AFI system. Color-contrast indices between the
colorectal lesions and the surrounding normal mucosa in the WLI, AFI and NBI images were calculated. The WLI, AFI, NBI and CE images were also evaluated by endoscopists using questionnaire-based visualization scores. Results. The color-contrast index seen in the AFI images (33.74 +/- 9.20) was significantly higher than that in either the WLI (11.14 +/- 6.14) or NBI images (11.72 +/- 7.12). There was no significant difference between the color-contrast indices of the WLI and NBI images. The mean AFI image visualization score (6.7 +/- 1.8) was significantly higher than that of WLI (6.0 +/- 1.7), and tended to be higher than that of the NBI images (6.1 +/- 1.6) when assessed by less-experienced endoscopists. Conclusions.