Respectively. Food intake did not significantly affected in each group. Effect of S. baicalensis ritonavir-induced decrease in the gastric emptying, as shown in Figure 4, in the control animals, which devan normal gastric ant betr gt 80%, suggesting that 80% of the test meal was emptied from the stomach min at 30. Rats treated with ritonavir, gastric emptying was significantly Hesperidin reduced to 21. 6 5% from 79 8 6% in control rats and 30 min. When rats were also ritonavir S. baicalensis extract was adversely Chtigung of gastric emptying induced by ritonavir significantly dose- Repealed dependent. Discussion drugs protease inhibitors have anti-retroviral drugs that produce some side effects, such as nausea and vomiting. Compliance is a prerequisite for an effective antiviral therapy for AIDS, should drug-induced side effects, compliance with treatment.
However, the links Selected Hlt drug-induced side effects reduce ideally free of other side effects. Kr utern And plants with their repertoire of several drugs as less serious non-toxic alternatives to drugs and can find real use in the treatment of drug-induced KU-0063794 side effects. In this study, we investigated whether ritonavir-induced gastrointestinal side effects from treatment with S. baicalensis botany k Can be mitigated. S. baicalensis is an effective, widely used in traditional Chinese medicine for its antimicrobial, antipyretic and anti-inflammatory. In recent years, S. baicalensis was found that several flavonoids fortune assets included. In this study, we investigated whether S. baicalensis can d Fight ritonavir-induced pica and delayed Siege gastric emptying.
We have shown that S. baicalensis treatment significantly reduces the side effects of gastrointestinal ritonavir caused. In this study, we showed that baicalein, one of the flavonoids in large en S. baicalensis found, ma Decisively. In the work of the grass HPLC analysis of the extract is shown S. baicalensis baicalein present at a concentration of 10 mg ? g. When baicalein was an important factor in the overall bioactivity t of extract and 10 g ? kg Baicalein dose should an anti-pica corresponds to produce that produced by 1 mg kg ? S. baicalensis extract. Our new work, we know that a dose of 10 g ? kg Rats is toxic. So we decided to use us for a lower dose of baicalein and tested the anti-pica in doses of 3 g kg ? and 1 g kg ?.
We sw Chung equal worth ritonavirinduced pica response in the groups treated with 3 g kg ? were revealed Baicalein and ? 1 mg kg S. baicalensis. Thus, with a dose of baicalein is 300 times lower than in the current S. baicalensis was equally effective, suggesting that an important part of baicalein fortune assets, the t for the activity Of S. baicalensis. The results also point to other components of the plant extract to act to counter the effectiveness of baicalein can k. Such dynamics may be to reduce as typical of a plant extract containing several active substances, the opposite k Can actions contribute to the toxicity of t Very powerful agents. The rat pica model wa