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wrote together Adenosine the manuscript; FP performed the in vitro experiments. All authors read and approved the final manuscript.”
“Introduction A growing body of evidence supports the notion that inflammation and colorectal cancer (CRC) are interrelated, including clinical observations and animal models [1]. The colonic mucosa is in constant contact with a high density of diverse microorganisms [2]. Antigens from these microbes are recognized by pattern-recognition receptors of the innate immune system. The toll-like receptor (TLR) family represents a critical part of this innate immune recognition, with each TLR recognizing pathogen-associated- or damage-associated-molecular patterns (DAMPs) [3]. In particular, TLR4 recognizes lipopolysaccharide (LPS) from the outer membrane of Gram-negative bacteria, the most common type of colonic bacteria [4]. Moreover, TLR4 is a receptor for DAMPs like hyaluronic acid and S100A9 [5, 6]. Our laboratory has studied the role of TLR4 in intestinal inflammation and colitis-associated neoplasia, supporting the function of TLR4 as a tumor promoter in human tissue and murine models [7, 8].