�?2. 22. Farruggio DC, Townsley FM, Ruderman JV. Cdc20 associates with the kinase aurora2/Aik. Proc Natl Acad Sci U S A 1999,96:7306�?1. 23. Zhou H, Kuang J, Zhong L, et al. Tumour epigallocatechin 989-51-5 amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation. Nat Genet 1998,20:189�?3. 24. Jeng YM, Peng SY, Lin CY, Hsu HC. Overexpression and amplification of Aurora A in hepatocellular carcinoma. Clin Cancer Res 2004,10:2065�?1. 25. Sasaki O, Kido K, Nagahama S. DNA ploidy, Ki 67 and p53 as indicators of lymph node metastasis in early gastric carcinoma. Anal Quant Cytol Histol 1999,21:85�?. 26. Sturgis CD, Caraway NP, Johnston DA, Sherman SI, Kidd L, Katz RL. Image analysis of papillary thyroid carcinoma fine needle aspirates: significant association between aneuploidy and death from disease.
Cancer 1999,87:155�?0. 27. Abad M, Ciudad J, Rincon MR, et al. DNA aneuploidy by flow cytometry is an independent prognostic factor in gastric cancer. Anal Cell Pathol 1998,16:223�?1. 28. Pihan GA, Purohit A, Wallace J, Malhotra R, Liotta L, Doxsey SJ. Centrosome defects can account for cellular and genetic changes that characterize prostate cancer progression. Cancer Y-27632 Res 2001,61:2212�?. 29. Pihan GA, Purohit A, Wallace J, et al. Centrosome defects and genetic instability in malignant tumors. Cancer Res 1998,58:3974�?5. 30. Lingle WL, Salisbury JL. Altered centrosome structure is associated with abnormal mitoses in human breast tumors. Am J Pathol 1999,155:1941�?1. 31. Ouchi M, Fujiuchi N, Sasai K, et al. BRCA1 phosphorylation by Aurora A in the regulation of G2 to M transition.
J Biol Chem 2004,279:19643�?. 32. Yang H, Ou CC, Feldman RI, Nicosia SV, Kruk PA, Cheng JQ. Aurora A kinase regulates telomerase activity through c Myc in human ovarian and breast epithelial cells. Cancer Res 2004,64:463�?. 33. Jiang Y, Zhang Y, Lees E, Seghezzi W. AuroraA overexpression overrides the mitotic spindle checkpoint triggered by nocodazole, a microtubule destabilizer. Oncogene 2003,22:8293�?01. Dar et al. Page 12 Mol Cancer Ther. Author manuscript, available in PMC 2011 February 2. NIH PA Author Manuscript NIH PA Author Manuscript NIH PA Author Manuscript 34. Katayama H, Sasai K, Kawai H, et al. Phosphorylation by aurora kinase A induces Mdm2 mediated destabilization and inhibition of p53. Nat Genet 2004,36:55�?2. 35. Liu Q, Kaneko S, Yang L, et al.
Aurora A abrogation of p53 DNA binding and transactivation activity by phosphorylation of serine 215. J Biol Chem 2004,279:52175�?2. 36. Dar AA, Zaika A, Piazuelo MB, et al. Frequent overexpression of Aurora Kinase A in upper gastrointestinal adenocarcinomas correlates with potent antiapoptotic functions. Cancer 2008,112:1688�?8. 37. Dar AA, Belkhiri A, Ecsedy J, Zaika A, El Rifai W. Aurora kinase A inhibition leads to p73 dependent apoptosis in p53 deficient cancer cells. Cancer Res 2008,68:8998�?004. 38. Thottassery JV, Westbrook L, Someya H, Parker WB. c Abl independent p73 stabilization during gemcitabine or 4, thio beta D arabinofuranosylcytosine induced apoptosis in wild type and p53 null colorectal cancer cells. Mol Cancer Ther 2006,5:400�?0. 39. Khwaja A. Akt is more than just a Bad kinase.
Nature 1999,401:33�?. 40. Guan Z, Wang XR, Zhu XF, et al. Aurora A, a negative prognostic marker, increases migration and decreases radiosensitivity in cancer cells. Cancer Res 2007,67:10436�?4. 41. Dar AA, Belkhiri A, El Rifai W. The aurora kinase A regulates GSK 3beta in gastric cancer cells. Oncogene 2009,28:866�?5. 42. Biggins S, Murray AW. The budding yeast protein kinase Ipl1/Aurora allows the absence of tension to activate the spindle checkpoint. Genes Dev 2001,15:3118�?9. 43. Tatsuka M, Katayama H, Ota T, et al. Multinuclearity and increased ploidy caus