In this situation sets, we report four instances from a nearby medical center in Karachi who had been diagnosed, treated and followed up for adamantinoma. Scientific studies in connection with infection will help us understand more about its features.We report a rare situation of Granular cellular astrocytoma (GCA) in a 59 years old male and also the issue related to its histopathological analysis. As Granular cell Astrocytoma cells resemble macrophages this situation is essential within the pitfalls with its analysis and also this report emphasizes in the problems linked to it. This particular client had neurological issues for 7 months and had not been examined. Later on he had a CT scan followed by a contrast-enhanced MRI associated with mind that revealed multiple focal lesions with surrounding oedema. After metastatic workup with PET/CT scan that was negative; he underwent craniotomy and biopsy for the lesion, which initially was reported as harmless. Later on his obstructs had been sent overseas read more and on further immunohistochemical markers it absolutely was eventually reported as Granular Cell Astrocytoma (Granular mobile Astrocytoma). Granular cell Astrocytoma is an extremely uncommon subtype of glioblastoma, which was first described by Markesbery et al in 1973 as a granular cellular tumour (GCT) into the brain/central neurological system. GCAs are rare and extremely intense mind tumours. The cells of GCA are distinguished from macrophages by their particular phrase of glial immune-stains, including glial fibrillary acid protein (GFAP). The perplexity in diagnosing GCA in this situation and its particular comparable characteristics as various other benign conditions; helps it be a unique uncommon mind tumour by which we must keep close track of whenever we have a fix in diagnosis of comparable brain lesions.Crossed Cerebellar Diaschisis (CCD) describes a depression of oxidative k-calorie burning and the flow of blood when you look at the cerebellum additional to a supratentorial lesion into the contralateral cerebral hemisphere. The pathophysiology isn’t clear but appears to be caused by abnormal neuronal connection of the main to the remote website. The diagnosis is generally done utilizing positron emission tomography (animal) and singlephoton emission CT (SPECT) scans. Just about all the reported situations of CCD are caused by acute ischemic stroke in grownups. Ergo, CCD additional to status epilepticus, exceptionally unusual and there is limited literature readily available upon it. This is really important as it’s conclusions can easily be mistaken for intense ischemic stroke and similar concurrent conditions. Correct analysis will help localize the explanation for the seizures and dramatically impact surgical choices. We present an instance of CCD in a kid with status epilepticus using MRI associated with the brain with DWI. Burkitt lymphoma (BL) exhibits a characteristic immunophenotype that is good for pan-B-cell antigens and germinal center markers while unfavorable for immature markers. A deviation from classic immunophenotype causes diagnostic confusion and may lead to untrue exclusion of BL. In some instances, overlapping clinical, morphological and immunophenotypic top features of BL and B lymphoblastic lymphoma (B-LL) could be of diagnostic challenge. Nevertheless, definitive delineation is of important value as a result of difference in treatment. We describe a case of BL in a kid with atypical features including lack of L3 morphology in diagnostic muscle and aberrant phrase of CD34, CD99 and BCL2 on immunohistochemistry. These results resulted in the interpretation of B-LL which was later on omitted by recognition of t (8;14). This unorthodox case not merely highlights the importance of cytogenetic assessment but additionally emphasizes the correlation of all diagnostic tools before making a definitive analysis. Consequently, reportingting but also emphasizes the correlation of all diagnostic resources before generally making a definitive analysis. Consequently, stating this instance can help in eliciting the high list of suspicion among pathologists for this remarkably strange Medical coding immunophenotype. A 42-year-old guy, known case of neurofibromatosis type 1 with café au belated places on trunk and extremities, neurofibromas, axillary freckling, pseudoarthrosis of distal tibia. He presented into the area cancer medical center with issue of huge size on horizontal chest wall surface. Incisional biopsy ended up being done and instance was clinically determined to have pleomorphic rhabdomyosarcoma. Immune/histochemical staining is good for desmin. Rhabdomyosarcoma is a malignant soft muscle tumour with unusual occurrence generally speaking populace. You can find few instances of pleomorphic rhabdomyosarcoma in NF 1 client are reported in literature. This example immunity ability reports a rare occurrence of rhabdomyosarcoma in person neurofibromatosis 1 client.A 42-year-old guy, known situation of neurofibromatosis kind 1 with café au belated spots on trunk area and extremities, neurofibromas, axillary freckling, pseudoarthrosis of distal tibia. He provided into the region disease medical center with problem of huge mass on lateral chest wall surface. Incisional biopsy was done and case was identified as having pleomorphic rhabdomyosarcoma. Immune/histochemical staining is good for desmin. Rhabdomyosarcoma is a malignant smooth tissue tumour with unusual occurrence overall population. You can find few cases of pleomorphic rhabdomyosarcoma in NF 1 patient are reported in literature.