demented.10 The diagnostic criteria for MCI are the following: (i) presence of memory complaint; (ii) normal activities of daily living; (iii) normal general learn more cognitive function; (iv) abnormal memory for age; and (v) absence of clinical dementia.11 Petersen et al11 demonstrated that, about 12% of individuals with MCI may progress to Alzheimer’s disease (AD), but a large proportion of MCI individuals will never convert, to dementia. Quantitative measurements of brain atrophy and activation studies with functional magnetic resonance Inhibitors,research,lifescience,medical imaging (MRI) have separated MCI decliners

fromnondecliners (see reference 12 for a comprehensive review). Other authors13 suggested that most individuals with MCI may eventually develop the neuropathology of AD, and question the usefulness of the definition MCI. The Diagnostic and Statistical Manual of Mental Disorders (DSM-IV)14 includes the Inhibitors,research,lifescience,medical category of age-related cognitive decline, which may be used whenever a decline in cognitive functions, as identified with specific neuropsychological instruments, lies ”within normal limits given the person’s age,“ with the provision that the cognitive impairment, should not be caused by a psychiatric disorder (eg, depression) or a neurological condition (eg, AD). The DSM-IV also includes criteria

Inhibitors,research,lifescience,medical for mild neurocognitive disorder with the provision that, these criteria are subject, to further study. The main feature of this syndrome is that the cognitive deficit should be the result, of a medical condition (Table II). The cognitive disorder is characterized by deficits in at least two cognitive domains, which may be confirmed through neuropsychological testing. The severity of the disorder Inhibitors,research,lifescience,medical is mild by definition, but. should be severe enough

to interfere with the patient’s social and/or workplace functioning. The main differential diagnoses of mild ncurocognitivc disorder are dementia (with relatively more severe cognitive deficits and more severe impairments in activities of daily living), Inhibitors,research,lifescience,medical a slowly evolving delirium, a postconcussion disorder, and cognitive deficits due to substance abuse or medications. The International Classification of Diseases-! Oth revision (ICD-10) Classification of Mental and Behavioral Disorders* Terminal deoxynucleotidyl transferase includes the category of mild cognitive disorder with the cautionary note that this construct is still under consideration (Table III). Table II Research criteria for mild neurocognitive disorder. Adapted from reference 14 with permission: American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders (4th edition) (DSM-IV). Washington, DC: American Psychiatric Press; … Table III Mild cognitive disorder. Adapted from reference 15 with permission: World Health Association. International Statistical Classification of Disease, and Related Health Problems- 10th revision. The iCD- 10 Classification of Mental and Behavioral Disorders. …