Preoperatively, bloodstream transfusion and management of recombinant element Schools Medical Ⅷ products were carried out. Surgery involved laparoscopic right hemicolectomy plus team 3 lymph node dissection. No problems, such as bleeding, happened during hospitalization. The individual was released on postoperative day 8. There have been various reports of laparoscopic surgery for clients with hemophilia. But, this case shows that it may be safely performed with planned factor Ⅷ supplementation in the perioperative period.Pertuzumab plus trastuzumab plus docetaxel program could be the first option for the first treatment of HER2-positive recurrent cancer of the breast. Nevertheless, docetaxel triggers numerous damaging activities. A 48-year-old woman was accepted to our medical center for a left breast tumor and was diagnosed with left breast cancer(T1N0M0, Stage Ⅰ, Luminal A). We performed a breast-conserving surgery and sentinel lymph node biopsy, accompanied by irradiation of this remaining components of the mammary gland and adjuvant treatment with tamoxifen. Three and a half years after the first surgery, she underwent regional resection due to chest wall surface recurrence of cancer of the breast. The recurrent tumor ended up being biodiversity change HER2-positive, and now we administered fluorouracil, epirubicin, cyclophosphamide( FEC)and paclitaxel plus trastuzumab. Liver metastases were confirmed on completion of pattern 11 of trastuzumab management, and also the program ended up being altered to pertuzumab plus trastuzumab plus docetaxel. A partial reaction ended up being seen after this regime. The next type of therapy was the administration of 5 cycles of T-DM1, which lead to stabilizing the illness. The liver metastases progressed, and also the regime ended up being changed to pertuzumab plus trastuzumab plus eribulin. Partial reaction had been seen after this regimen for liver metastases without serious adverse events(20 cycles).A 48-year-old female went to former medical practitioner with abdominal discomfort and bloating. She was suspected of getting pancreatic tumor and known our hospital. Abdominal dynamic CT showed multilocular cystic cyst when you look at the pancreatic tail, and chest CT showed several lung nodules. From the results, the patient was diagnosed mucinous cystic carcinoma(MCC)with lung metastases. We performed distal pancreatectomy when it comes to very first and lung resection after pancreatectomy. All things considered, the pathological analysis was MCC and metastatic lung cancer tumors through the MCC. The adjuvant chemotherapy had not been done. Eleven months after pancreatectomy and half a year after lung resection, the in-patient is still alive without recurrence.The instance had been a woman in her own 50s. Complete pelvic resection ended up being done for advanced rectal cancer(cT4b[vagina]N3M0, cStage Ⅲc), after neoadjuvant chemoradiation treatment. Five months following the operation, she was struggling to sit due to severe right back pain. Spinal MRI disclosed numerous bone metastases and lumbar cracks. In inclusion, dysphagia and dysarthria rapidly progressed practically simultaneously with right back pain. At first, mind metastasis ended up being suspected, but mind MRI unveiled Collet-Sicard syndrome due to skull base metastasis. Irradiation into the head base and large cervical spine, thoracolumbar spine had been started. After irradiation, her back pain and cranial nerve signs improved. She ended up being discharged and received palliative therapy. About four weeks after discharge, she ended up being hospitalized for recurrent dysphagia and passed away on time 5 of hospitalization. Collet-Sicard syndrome is brought on by problems for the cranial nerves Ⅸ to Ⅻ and is frequently brought on by a tumor. Trauma, vasculitis, and interior carotid artery dissection happen reported as other notable causes. Signs such hoarseness, dysarthria, tongue atrophy, dysphagia, and headache happen reported. Collet-Sicard problem as a result of bone tissue metastasis of colorectal disease were really rare, and we discovered only one other report. We report our instance with a few literature considerations.Here, we report an instance of successful medical resection of expansive-growth acinar cellular carcinoma. A 59-year-old guy was referred to an area medical center with stomach distention. CT disclosed a sizable stomach tumor. Afterwards, he had been regarded our medical center. Actual assessment revealed a large tumor on his left top abdomen without pain. CT disclosed an advanced 18 cm-sized expansive-growth tumefaction on the left flank, suggesting a primary pancreatic tumor. EUS-FNA yielded a diagnosis of adenocarcinoma. Imaging conclusions were not typical for pancreatic ductal carcinoma. We performed distal pancreatectomy with splenectomy, transverse colon resection, and proximal gastrectomy. Pathological findings revealed a tumor, measuring 19.5×16.5×15.5 cm, originating through the pancreatic body, positive for trypsin, chymotrypsin, and elastase, constant with an analysis of acinar cell carcinoma, pT3, N0, M0. Four courses selleck of adjuvant chemotherapy with S-1 had been provided, in addition to patient happens to be alive without recurrence for 10 months.A 77-year-old man with rectal cancer had been accepted to the hospital. After neoadjuvant chemotherapy, laparoscopic abdominoperineal resection of rectum with D3 dissection had been done. The pathological analysis ended up being poorly classified carcinoma, pT3, N1a, M0, pStage Ⅲa. Adjuvant chemotherapy had not been performed. Fifteen months after operation, their main complaint had been fatigue. Thrombocytopenia and elevation of tumor maker ended up being recognized by bloodstream test and disseminated intravascular coagulation(DIC)was suspected. He had been admitted to the medical center and we started anti DIC therapy immediately. Bone scintigraphy revealed several bone metastases, then we diagnosed disseminated carcinomatosis associated with the bone tissue marrow. He died 10 days after hospitalization. Disseminated carcinomatosis regarding the bone marrow with cancer of the colon is uncommon and prognosis is quite poor.