breath test; 4 GERD; Presenting Author: XIONG YANYAN Correspondi

breath test; 4. GERD; Presenting Author: XIONG YANYAN Corresponding Author: XIONG YANYAN Affiliations: ying tan people’s hospital Objective: To compare the eradication efficacy of 10-day sequential therapy and quadruple therapy for patients with failed H. pylari eradication. Methods: Eight-nine patients who had failed H. pylori eradication were randomly divided two groups. Forty-five patients received a 10-day sequential therapy [rabeprazole (10 mg, twice daily) plus amoxicillin (1000 mg, twice daily) for the first days, followed by rabeprazole (10 mg), clarithromycin

(500 mg) and metronidazole (400 mg) twice daily for the Cilomilast remaining 5 days]. Forty-four patients received quadruple therapy [rabeprazole (10 mg), clarithromycin (500 mg) and metronidazole (400 mg)], and bismuth subcitrate 220 mg, twice daily for 7 days]. Four weeks after the end of reeatment, 14C-urea breath test was re-examined to assess H. pylori eradication rate. Results: The eradication rate of

the 10-day sequential therapy was 91.1%, and merely 75% for quadruple therapy group. The difference between the two groups was significant (P < 0.05). There was no difference in incidence of side of fects between the two grorps (P > 0.05). Conclusion: Both http://www.selleckchem.com/products/XL184.html sequential therapy and quadruple therapy can be used as a rescue therapy for eradication of H. pylori in patients with failed H. pylori in patients cradication. And the sequential therapy is more effective and better treatment for pylori eradication. Key Word(s): 1. Sequential therapy; 2. Helicobacter

pylori; 3. Qradruple therapy; Presenting Author: TINGTING XIE Additional Authors: BO JIANG Corresponding Author: BO JIANG Affiliations: Department of Gastroenterology, Nanfang Hospital, Southern Medical University Objective: he role of H. pylori infection in the pathogenesis of Gastro-esophageal reflux disease (GERD) is controversial. We aimedto evaluate the relationship between H. pylori and GERD and confirm whether the eradication is associated with the development of GERD. Methods: Case-control click here studies comparing the prevalence of H. pylori infection between patients with and those without endoscopic GERD, cohort studies (A) comparing the incidence of de novoendoscopicGERD between patients with and those without anti-H. pylori eradication therapy and cohort studies (B) comparing the incidence of endoscopicGERD between H. pylori positive patients with and those without successful eradication were included. Moreover, effects of H. pylori eradication on the development of endoscopicGERD in randomized controlled trials (RCTs) were also analyzed. Results: 44 studies were analyzed, including 20 case-controls, 3 cohort studies (A), 9 cohort studies (B) and 12 RCTs. Whereas case-control studies showed a lower prevalence of H. pylori infection in patients with GERD (OR = 0.67, 95% CI: 0.51–0.88), cohort studies (A) showed an increasedincidence of de novo GERD in patients whose H. pylori infection was successfully eradicated (RR = 2.50, 1.

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