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“Background Most people infected with HIV-1 are dually infected with herpes simplex virus type 2. Daily suppression of this herpes virus reduces plasma HIV-1 concentrations, but whether it delays HIV-1 disease progression is unknown. We investigated the effect of aciclovir on HIV-1 progression.\n\nMethods In a trial with 14 sites in southern Africa and east Africa, 3381 heterosexual people who were dually infected with herpes simplex virus type 2 and HIV-1 were randomly assigned in a 1:1 ratio to aciclovir 400 mg orally twice daily or placebo, and were

followed up for up to 24 months. Eligible participants had CD4 cell counts of 250 cells per mu L or higher and were not taking antiretroviral therapy. We used block randomisation, and patients ERK inhibitors high throughput screening and investigators were masked to treatment allocation. Effect of aciclovir on HIV-1 disease progression was defined by a primary composite endpoint of first occurrence of CD4 cell counts of fewer than 200 cells per mu L, antiretroviral therapy initiation, or non-trauma related death. As an exploratory analysis, we assessed the endpoint of CD4 falling to <350 cells per mu L. Analysis was by intention to treat. The trial is registered with ClinicalTrials.gov, number Prexasertib NCT00194519.\n\nFindings At enrolment, the median CD4 cell count was 462 cells per mu L and median HIV-1 plasma RNA

was 4.1 log(10) copies per mu L. Aciclovir reduced risk of HIV-1 disease progression by 16%; 284 participants Evofosfamide chemical structure assigned aciclovir versus 324 assigned placebo reached the primary endpoint (hazard ratio [HR] 0.84, 95% CI 0.71-0.98, p=0.03). In those with CD4 counts >= 350 cells per mu L, aciclovir delayed risk of CD4 cell counts falling to <350 cells per mu L by 19% (0.81, 0.71-0.93, p=0.002).\n\nInterpretation The role of suppression of herpes simplex virus type 2 in reduction of HIV-1 disease progression before initiation of antiretroviral

therapy warrants consideration.”
“Introduction\n\nSentinel lymph node biopsy (SLNB) has progressively replaced complete axillary lymph node dissection in the evaluation of breast cancer patients with clinically node-negative disease. Our study investigates the rate of and risk factors involved in sentinel node identification failure.\n\nMaterials and methods\n\nWe collected data on SLNBs performed during 2002-2010, focusing on tumor, patient, and breast characteristics, radioactivity parameters, and operators’ experience. Data were analyzed by R (v2.14.2), considering significance at P values lower than 0.05.\n\nResults\n\nAmong 1050 women who underwent an SLNB, the rate of identification failure was 2% (23/1050), which, on bivariate analysis, was seen to be significantly influenced (P<0.