All the children were 12-14 years old We measured anthropometric

All the children were 12-14 years old. We measured anthropometric parameters by a standardized method and the percentage of fat using the simple 2-site skinfold method. Additionally, we calculated the percentage of body composition (Matiegka) and the components of somatotype (Heath-Carter). Statistical significance was estimated at the

level of p<0.05 by ANOVA test.

Results: The asthmatic boys were significantly shorter than the non-asthmatic (p=0.015), however, we did not find any significant this website differences in weight and/or BMI in boys nor girls. The asthmatic boys had significantly higher fat mass % than the non-asthmatic ones (p<0.001). Moreover, they had significantly lower muscle mass % (p<0.001) as well as the bone mass % (p<0.001). The asthmatic girls had higher fat mass % than the non-asthmatic ones (p=0.028) and lower muscle mass % (p<0.001). The simple 2-site skinfold method also showed higher fat % in the asthmatic boys (p<0.001) but not in the girls. Examining the Heath-Carter somatotype components, the higher endomorphy was the only significant difference in asthmatic boys (p<0.001) and near significant in asthmatic girls (p=0.053).

Conclusion: Examination of the BMI alone is not sufficient in asthmatic children because of their high percentage of fat. That is why additionally testing fat % is recommended.”
“Purpose: Some find more scientific studies show decreased bone

mineral density and increased fracture frequency in adult patients with cystic fibrosis (CF). The mechanism for early bone loss in CF patients

are multifactorial: chronic pulmonary inflammation, malnutrition, reduced physical activity, delayed pubertal maturation. The aim of this study was to assess bone metabolism markers with special attention paid to osteoprotegerin (OPG) and receptor activator of nuclear factor kappa B ligand (RANKL) balance in CF children.

Material and Methods: The study included 35 children with diagnosed CF and 35 healthy controls aged 5-9 years (median 7.0 years). 3-deazaneplanocin A in vitro Serum levels of fat soluble vitamins were measured by chemiluminescence (vitamin D) and HPLC (vitamins A, E) methods. Concentrations of bone metabolism markers were determined by immunoenzymatic assay.

Results: Mean levels of fat soluble vitamins (A, D, E) were lower in patients with CF compared to controls. In CF children we observed a significant (p<0.01) decrease in concentration of bone formation marker (osteocalcin) and similar bone resorption markers (CTX, TRACP5b) in comparison with healthy children. The serum level of OPG was significantly lower (p<0.05) and RANKL nearly 2-fold higher in patients with CF than in the healthy ones. The ratio of OPG to RANKL was about 2-fold lower in children with CF compared to healthy peers (p<0.01).

Conclusion: In CF children, an imbalance between bone formation and resorption processes occurs.

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