[4] Recent molecular studies have shown that the epithelial component is polyclonal and does not exhibit clonal allelic losses, suggesting that this tumor is not a true neoplasm.[16] Recent studies have also reported the presence of selleck chemicals B-cells (CD20), NK (CD56) and T (CD3), including helper subtypes (CD4) and suppressor (CD8) in the tumor’s stroma, something similar to that of normal or reactive lymph nodes. Also, it was found that CD20-positive B-lymphocytes were located in the germ centers and peripheral B-area while CD3-positive T-lymphocytes are located interfollicularly.[17] Surgeons are traditionalists, and the early experience of our peers has colored current surgical opinion and slowed the introduction of conservative surgery for the benign parotid lump.

This situation is now changing, and centers with experience of treating parotid tumors increasingly recognize that benign tumors can be removed safely by techniques much less invasive than a formal parotidectomy.[16] This surgical modality is based on meticulous dissection immediately outside the tumor capsule with preservation of the facial nerves.[18] In view of the possible association of WT with extra-salivary neoplasms, extensive workup of the patients harboring multiple WT is, therefore, indicated and long-term follow-up is mandatory, due to the possible occurrence of metachronous salivary and extra-salivary tumors even after prolonged time intervals.[3] Rarely, either the epithelial or lymphoid component of WT can undergo malignant transformation with an estimated incidence of less than 0.1%.

In order of frequency, the commonest carcinomas are squamous cell carcinoma, oncocytic carcinoma, adenocarcinoma, undifferentiated carcinoma, mucoepidermoid carcinoma and Merkel cell carcinoma.[5] Complications must be unusual and of low frequency for the surgical resection of a WT, including some complications considered of minor importance, such as paresis of the ear lobe resulting from manipulation and/or section of the auricularis magnus branch of the superficial cervical plexus. The auricularis magnus nerve, in its path toward the ear lobe, may pass through the tumor, hampering Carfilzomib the dissection. Another complication of lesser importance is the change of facial contour due to resection of a large portion of the parotid gland.[19] None of the complications, however, seemed to appear in our case. Footnotes Source of Support: Nil Conflict of Interest: None declared.
A 28-year-old male patient presented with a complaint of enlarging swelling of 1 month duration in the right anterior floor of the mouth which was otherwise asymtomatic.