997, P=0.007), inferior retinal break (OR=14.127, P<0.0001) and better preoperative BCVA (OR=1.636 P<0.0722).\n\nCONCLUSION: Atrophic retinal break, inferior retinal break and better preoperative BCVA are the independent risk factors related to chronic RRD.”
“The aim of this work was to determine the chemical constituents and in vitro antimicrobial activity of the essential oil (EO) of the aerial parts of Mentha sueveolens spp. insularis grown in Sardinia (Italy) against probiotic and starter microorganisms. The gas chromatography-mass spectrometry (GC-MS) analysis allowed to identified 34 compounds, most of oxygenated

monoterpene compounds (82.5%) and among them, pulegone was found as major compound (46.5%). The agar diffusion test carried out employing the EO of Mentha suaveolens spp. insularis showed a low antibacterial activity, GSK2879552 molecular weight in particular no action was noticed for probiotic bacteria belonging to lactic acid bacteria groups, whereas almost all yeasts strains tested were inhibited. The automated microtitter dilution assay showed SU5402 molecular weight a clear effect at increasing concentration of EO on the specific growth rate (mu) and extension

of the lag phase (lambda) only for S. xylosus SA23 among bacteria and for Saccharomyces cerevisiae, Tetrapisispora phaffii CBS 4417, Metschnikowia pulcherrima, and Candida zemplinina among yeasts. Results obtained in this work allow us to broaden the knowledge on the effect of EOs on probiotic and food-related microorganisms.\n\nPractical Application\n\nMentha suaveolens spp. insularis may be used in combination with probiotic bacteria into the food matrix or encapsulated in coating and edible films for food preservation.”
“Doxorubicin, which is a positively charged anti-cancer drug, was encapsulated into the micelles formed by copolymers consisting of methoxy poly(ethylene glycol), negatively charged aspartic acid oligomer and poly(epsilon-caprolactone) (mPEG-Asp-PCL). The micelles showed an intensity-averaged diameter of 73.0 +/- 30.6 nm measured by dynamic light scattering. The diameter of doxorubicin loaded micelles increased slightly to 75.8 +/- 26.2 nm. The doxorubicin-loading

and efficiency into the micelles were 15.1% URMC-099 and 44.5%, respectively. The drug-loaded micelles were stabilized ionically using divalent calcium cations and displayed a size of 78.1 +/- 24.3 nm. The stabilized micelles showed the typical two-phase release patterns, which were the relatively rapid release of 53% doxorubicin in the first 24 h, and then showed the sustained release to 65% of more than 90 h. On the other hand, doxorubicin release from the non-stabilized micelles was retarded and did not exceed 5% in 24 h because the positively charged doxorubicin at pH 7.4 in the absence of cations was still retained in the micelles through ionic interactions with the carboxylic acids of aspartic acid residues. At pH 3.