40 eligible MWoA patients and 20 matched healthy volunteers were included in the study. Regional homogeneity (ReHo) analysis was used to identify the local features of spontaneous brain activity in MWoA patients stratified by disease duration, and analysis was performed to investigate the correlation of overlapped brain dysfunction in MWoA patients with different disease duration (long-term and short-term) and course of disease.
Compared with healthy controls, MWoA patients with long-term disease duration showed comprehensive neuronal dysfunction than patients with short-term
disease duration. In addition, increased average ReHo values in the thalamus, brain stem, and temporal pole showed significantly positive correlations with the disease duration. On the contrary, ReHo values were negatively correlated with the duration of disease in the anterior cingulate cortex, insula, posterior cingulate cortex and superior BAY 11-7082 purchase occipital gyrus.
Our
findings of progressive brain damage in relation to increasing disease duration suggest that migraine without aura is a progressive central nervous disease, and the length of the disease duration was one of the key reasons to cause brain dysfunction in MwoA patients. The repeated PD173074 manufacturer migraine attacks over time result in resting-state abnormalities of selective brain regions belonging to the pain processing and cognition. We predict that these brain regions are sensitive neuroimaging markers for reflecting the disease duration of migraine patients without aura.”
“One-dimensional transition metal (TM) nanowires can be formed on a stepped Stem Cell Compound Library cell line Cu(111) surface. The basic template is an embedded Fe chain at one-atom distance away from the upper edge of the monoatomic surface step, supplying the deposition of 3d TM chains from V to Co to form on top of the Fe chain. Density functional theory (DFT) is applied to calculate the magnetic properties of these TM-Fe wires. Exchange parameters are extracted from the DFT calculations. A classical Heisenberg model is used in Monte Carlo
simulations to study finite temperature effects. (C) 2010 American Institute of Physics. [doi: 10.1063/1.3368794]“
“Background: Evaluation of the need for prophylactic internal cardiac defibrillators among patients with ischemic cardiomyopathies should be deferred until at least 3 months after revascularization procedures to allow adequate time for recovery of ventricular function.
Methods: Among patients with left ventricular systolic dysfunction (LVSD) who undergo coronary artery bypass grafting (CABG), the proportion of patients who are risk stratified postoperatively with reassessment of left ventricular ejection fraction (LVEF) is unknown.
Results: One hundred and six patients with LVSD (LVEF < 40%) who underwent CABG during 20042006 and survived 3 months post CABG were evaluated. Follow-up was assessed by chart review and telephone contact.