Figure 1 Ulceration, congestion, and inflammation in Group C (H&E x100) (A). Repair with connective tissue in Group C: anastomotic line (H&E x100) (B). Repair and surface epithelialization in Group C (small bowel epithelium) (H&E x100) … Figure 2 Visible intact pouch before excision (A). Contrast study of the direct coloanal anastomosis specimen (B). Contrast

study of the coloplasty specimen (C). #NVP-LDE225 nmr keyword# Contrast study of the ileal J pouch specimen (D). After biopsy, all the samples were filled by contrast and evaluated by an expert radiologist. In comparison, the volume increase in the pouch group (figure 2B) was markedly higher than the volume increase in the coloplasty (figure 2C) and direct anastomosis Groups (figure 2D). The dogs’ weights in the three groups under study were not markedly different. The primary volume of the rectum, volume after 8 weeks (end of the study), and volume increase for each dog were measured. The volume increase in each group was also calculated Inhibitors,research,lifescience,medical (table 3). Table 3 Volume of the primary rectum and neorectum in all the three groups under study Considering Inhibitors,research,lifescience,medical Group A (the control group), the percentage of the increase in the volume of the rectum (the volume of the primary rectum in comparison to the volume

of the neorectum at the end of the study) was as follows: A1: 150cc            180cc (20% ↑) A2: 150cc             Inhibitors,research,lifescience,medical 200cc (33% ↑) A3:140cc              150cc (7.1% ↑) A4: 170cc             210cc (23.5% ↑) Moreover, the mean volume increase in Group A was measured as 20.9%. The percentage of the volume increase in the place of the rectum in Group B (the coloplasty group) was as follows: B1: 160cc           Inhibitors,research,lifescience,medical 180cc (12.5% ↑) B2: 130cc          150cc

(15% ↑) B3: 140cc          180cc (28.5% ↑) B4: 130cc         170cc (31% ↑) In addition, the mean volume increase in Group B was equal to 21.7%. Finally, the percentage of the volume increase in the place of the rectum in Group C (J-pouch) was as follows: C1:170cc           350cc 17-DMAG (Alvespimycin) HCl (106% ↑) C2:155cc           380cc (145% ↑) C3:150cc           300cc (100% ↑) C4: 90cc            200cc (122% ↑) Also, the mean volume increase in Group C was 118.2%. Discussion Although colon J-pouch is the best method of operation after removing the rectum, J-pouch coloanal anastomosis was not possible in 26.2% of low rectal cancer patients who had undergone low ant resection plus total mesorectal excision.3 This situation occurs in the following conditions: Narrow pelvic, Bulky sphincter, Diverticulitis, Insufficient colon length, Pregnancy, Complex surgery, Distant metastasis3 Nowadays, the low ant resection operation, accompanied by total mesorectal excision (TME) is considered the standard treatment for rectal cancers.