The primary outcome variable was cardiac index.
Results:
No difference in cardiac index was observed between the two groups (P = 0.594). Both drugs increased cardiac index, dopexamine from 3.9 +/- 0.6 CB-5083 ic50 to 4.7 +/- 0.8 l center dot min(-1)center dot m(-2) (P = 0.003) and dobutamine from 4.1 +/- 0.7 to 4.8 +/- 0.7 l center dot min(-1)center dot m(-2) (P = 0.004). During treatment with dobutamine, children presented with significantly higher mean arterial pressure (P = 0.003) and systemic vascular resistance index (P = 0.026).
Conclusions:
This trial demonstrates that low-dose dobutamine and dopexamine both increase
cardiac index during pediatric cardiac surgery but with different hemodynamic effects.”
“Background: It is generally accepted that an excessive production of reactive oxygen species plays an important role in acute renal failure secondary to ischemia and reperfusion. tert-Butylhydroquinone (tBHQ) is a well-known antioxidant. In this study, we evaluated
whether tBHQ pretreatment prevented renal damage induced by this website ischemia and reperfusion (I/R).
Methods: Four groups of rats were studied: (a) control-sham (CT), (b) tBHQ-sham (tBHQ), (c) I/R and (d) tBHQ + I/R. Intraperitoneal (i.p.) injections of tBHQ (50 mg/kg) were given to the tBHQ and tBHQ + I/R groups and 3% ethanol/isotonic saline solution to the CT and I/R groups. Animals were killed 24 hours after I/R.
Results: tBHQ attenuated I/R-induced renal dysfunction, structural damage, oxidative/nitrosative stress, glutathione depletion and the decrease in several antioxidant enzymes.
Conclusion: The renoprotective effect of tBHQ on I/R injury was associated with the attenuation in oxidative/nitrosative stress and the preservation of antioxidant enzymes.”
“Objective: The objective of this study was to find out the percentage of
preterm infants that needed treatment for patent ductus arteriosus (PDA), when treatment decision was based on clinical signs and symptoms, besides echocardiographic findings.
Methods: Daily echocardiographic evaluation was conducted in 39 preterms <= 29(6/7) weeks’ gestation. Patients with ductus arteriosus were closely followed-up for clinical symptoms of PDA for treatment see more decision until ductus arteriosus was closed either spontaneously or by treatment.
Results: PDA was found in 25 (64%) infants. Mean gestational age and birth weight (BW) of the patients with PDA were 27.8 +/- 1.2 and 998 +/- 221 g, respectively. PDA closed spontaneously or had minimal ductal shunting before any signs and symptoms attributable to PDA were observed in 16 (41%) infants. Mean ductus size/BW ratio and mean left atrial/aortic root ratio were significantly higher in 9 (23%) symptomatic patients (2.06 +/- 0.75 versus 1.32 +/- 0.75 mm, p = 0.012 and 1.31 +/- 0.52 versus 1.19 +/- 0.2 mm, p = 0.043, respectively). PDA closure was observed after the first dose of ibuprofen in six of nine patients.