Microbiology 2006, 75:390–397.CrossRef 38. Moxon R, Bayliss C, Hood D: Bacterial contingency loci: the role of simple sequence DNA repeats in bacterial JAK inhibitor adaptation. Annu Rev Genet 2006, 40:307–333.PubMedCrossRef

39. Prouzet-Mauleon V, Hussain MA, Lamouliatte H, Kauser F, Megraud F, Ahmed N: Pathogen evolution in vivo: genome dynamics of two isolates obtained 9 years apart from a duodenal ulcer patient infected with a single Helicobacter pylori strain. J Clin Microbiol Copanlisib purchase 2005, 43:4237–4241.PubMedCrossRef 40. Drenkard E, Ausubel FM: Pseudomonas biofilm formation and antibiotic resistance are linked to phenotypic variation. Nature 2002, 416:740–743.PubMedCrossRef 41. Mahenthiralingam E, Campbell ME, Speert DP: Nonmotility and phagocytic resistance of Pseudomonas aeruginosa isolates from chronically colonized patients with cystic fibrosis. Infect Immun 1994, 62:596–605.PubMed 42. Mahenthiralingam E, Campbell ME, Foster J, Lam JS, Speert DP: Random amplified polymorphic DNA typing of Pseudomonas aeruginosa isolates recovered from patients Selleck STI571 with cystic fibrosis. J Clin Microbiol 1996, 34:1129–1135.PubMed 43. A Worlitzsch D, Tarran R,

Ulrich M, Schwab U, Cekici A, Meyer KC, Birrer P, Bellon G, Berger J, Weiss T, Botzenhart K, Yankaskas JR, Randell S, Boucher RC, Doring G: Effects of reduced mucus oxygen concentration in airway Pseudomonas infections of cystic fibrosis patients. J Clin Invest 2002, 109:317–325. 44. Lee B, Haagensen JA, Ciofu O, Andersen JB, Høiby N, Molin S: Heterogeneity of biofilms formed by nonmucoid Pseudomonas aeruginosa isolates from patients with cystic fibrosis. J Clin Microbiol 2005,

43:5247–5255.PubMedCrossRef 45. O’Toole GA, Kolter R: Flagellar and twitching motility are necessary for Pseudomonas aeruginosa biofilm development. Mol Microbiol 1998, 30:295–304.PubMedCrossRef 46. Klausen M, Heydorn A, Ragas P, Lambertsen L, Aaes-Jørgensen A, Molin S, Tolker-Nielsen T: Biofilm formation by Pseudomonas aeruginosa wild type, flagella and type IV pili mutants. Mol Microbiol 2003, 48:1511–1524.PubMedCrossRef 47. Chiang P, Burrows LL: Biofilm formation by hyperpiliated mutants of Pseudomonas aeruginosa . J Bacteriol 2003, 185:2374–2378.PubMedCrossRef 48. Deligianni E, Pattison S, Berrar D, Ternan Niclosamide NG, Haylock RW, Moore JE, Elborn SJ, Dooley JS: Pseudomonas aeruginosa cystic fibrosis isolates of similar RAPD genotype exhibit diversity in biofilm forming ability in vitro. BMC Microbiol 2010, 8:38.CrossRef 49. Döring G, Knight R, Bellon G: Immunology of cystic fibrosis. Edited by: Hodson ME, Geddes D. Cystic fibrosis, Arnold, London, England; 2000:109–141. 50. Jobsis Q, Raatgeep HC, Schellekens SL, Kroesbergen A, Hop WCJ, de Jongste CJ: Hydrogen peroxide and nitric oxide in exhaled air of children with cystic fibrosis during antibiotic treatment. Eur Respir J 2000, 16:95–100.PubMedCrossRef 51.