“DNA methylation has long been considered a very stable DN


“DNA methylation has long been considered a very stable DNA modification in mammals that could only be removed by replication in the absence of remethylation – that is, by mere dilution of this epigenetic mark

(so-called passive DNA demethylation). However, in recent years, a significant number of studies have revealed the existence of active processes of DNA demethylation in mammals, with important roles in development and transcriptional regulation, allowing the molecular mechanisms of active DNA demethylation to be unraveled. In this Selleck TPX-0005 article, we review the recent literature highlighting the prominent role played in active DNA demethylation by base excision repair and especially by TDG.”
“The protective effect of amifostine against cyclophosphamide (CP) was evaluated on mouse oocytes.

Female mice were divided into four groups as follows: group1: cyclophosphamide (CP) (75 mg/kg, i.p) injection, group2: amifostine (250 mg/kg, i.p) injection, group3: amifostine (250 mg/kg, i.p) administered prior to CP (75 mg/kg, i.p)

injection, Control group with injection of saline. About 21 days after injection, in vitro maturation (IVM) of oocytes was recorded. Furthermore the percentage of aneuploid oocytes was determined.

In the CP group IVM rate was significantly decreased and aneploidy rate was significantly increased when compared to other Selleckchem Combretastatin A4 groups (p < 0.05). With the administration of Amifostine prior to CP injection IVM rate was increased and aneploidy rate was decreased.

Depletion Selleck HSP990 in IVM rate with administration of CP is due its adverse effects on oocyte quality. Amifostine administration prior to CP

injection appears to modulate deleterious effects of CP on oocytes.”
“Objective: To present the fascinating, controversial, and tumultuous history of tympanic cautery as a form of myringoplasty and describe the relevance of work more than 150 years old to modern practice and research.

Data Sources: More than 70 English, French, and German articles and books published over the last 400 years, which refer to some aspect of tympanic membrane cautery.

History: The first recorded use of silver nitrate to stimulate closure of tympanic membrane perforations is by William Wilde in 1848. Since then, numerous modifications of this technique have been used, and its significance has waxed and waned in response to events within the speciality of otology and the wider world.

Conclusion: There are lessons to be learned from the rise and fall of this once widely practiced technique. There exists a school of thought that believes that the significance of cautery lies not only in the history of otology but also in its future.”
“Neodymium-doped yttrium aluminium garnet (Nd:YAG) laser systems (with a power output up to 100 W, wavelength 1318 nm) have been introduced into clinical practice for resecting lung metastases.

Leave a Reply

Your email address will not be published. Required fields are marked *

*

You may use these HTML tags and attributes: <a href="" title=""> <abbr title=""> <acronym title=""> <b> <blockquote cite=""> <cite> <code> <del datetime=""> <em> <i> <q cite=""> <strike> <strong>