He PCP model Our previous FAK inhibitor in clinical trials studies showed a selective deficit of DA turnover in the pr Limbic cortex and DLPFC weeks after treatment with PCP in our model, not 1E2 primate PCP. Even after 28 days, a lower deficit, but significant use of DA was still in the pr DLPFC, also in the cerebral cortex Limbic The decline was more pronounced. In the orbital frontal cortex and nucleus accumbens DA utilization was not impaired Chtigt. Were no significant changes Changes in other cortical regions or subcortical observed examinees at any time after PCP treatment. Surprisingly, we found a significant decline in the use of 5HT receptors in monkeys with PCP in the PCP orbitofrontal cortex differentiated and control subjects, these M treated eliminates possibility. Third, PCP-exposed animals have a general defect in their R Ability to know about the associative relationships between discriminanda and reward, however, this is not an economical explanation Tion of our results, there were no differences between the groups, the M Possibility, a new visual experience discrimination, although this phase is also an issue of the spot 鈥 檚 F is based ability to develop relationships Pavlov. Closing Lich k Nnten deficits in reversal learning to an Unf Ability to inhibit previously learned response, if the rules are attributed to the change in position. These M Possibility is supported by a significant amount of data. In general, increased Error in monkeys exposed ht reversal of PCP in the research phase inversion was limited, if the offense against the rule already learned the st Is strongest. In addition, the deficit was specific to opposite inversion, such as acquisition, and the need to inhibit a previously learned response is one of the few factors that distinguish these two conditions. Third, it presents Lich learning term defect in the object retrieval / detour task, ben at the issues To reach the innate tendency directly inhibit the reward of learning strategy to achieve detour, also supports a failure of inhibition of the response Agomelatine 138112-76-2 to these questions . Taken together, we suggest that subchronic PCP Changed specific issues requiring response inhibition, and thus m for may have gr Ere impact on any task that requires changing or switching behavior have. This proposal should be further investigated clearly in rodents and nonhuman primate models. 4.3. Neuro-anatomical and neurochemical considerations of observational studies in humans and experimental studies in nonhuman primates have implicated the inferior frontal / orbitofrontal cortex as a reversal learning underlying substrate or other essential tasks with response inhibition. Be the inferior frontal cortical regions in response inhibition and reversal learning involved exert their actions through corticostriatal projections or by direct hyper said the final circuit was focused studies, identified responses to stop quickly. Recent studies suggest that the direct hyper-operatively with the interruption of production-oriented goals of the global behavior, t pleased that selective inhibition of specific reactions associated. In reversal learning task requires the selective retention of only one answer, need access to other behaviors nor the lon.